سامانه کنگره های دانشگاه علوم پزشکی و خدمات بهداشتی و درمانی آذربایجان غربی

صفحه اصلی / بیستمین همایش سالیانه بیماری های شایع گوارش و کبد کودکان ایران و دومین همایش بین المللی چاقی کودکان

Do Probiotics Outperform Synbiotics in the Management of Pediatric NAFLD? A Review

نویسندگان :

Sanaz Bohlouli Sardroudi¹ Zahra Firoozi² Sara Arefhosseini³ Mehrangiz Ebrahimi-Mameghani⁴

1- Tabriz University of Medical Sciences 2- Tabriz University of Medical Sciences 3- Tabriz University of Medical Sciences 4- Tabriz University of Medical Sciences

کلمات کلیدی :

Non-alcoholic fatty liver disease،Synbiotics،Children،Probiotics

چکیده :

Background and Aim: To date, the prevalence of Non-alcoholic fatty liver disease (NAFLD) among children has increased dramatically. Due to the multi-metabolic nature of the disease, functional foods have gained a great interest. A number of studies have demonstrated the favorable effects of probiotic supplementation in relieving lipidemia, liver enzymes as well as liver steatosis in children with NAFLD, while the effects of synbiotics and their probable superiority in comparison with prebiotics in this population remains unclear. This study aimed to compare the clinical effectiveness of synbiotics versus probiotics supplementation in pediatric with NAFLD. Methods: PubMed, Scopus, Web of Science, and Google Scholar databases were searched using Mesh terms and non-MeSH terms including: ("Non-alcoholic Fatty Liver Disease" OR " Fatty Liver") AND (Probiotics OR Synbiotics OR "fermented food") AND (Child AND Adolescent). Data were compiled from a selection of studies on effect of synbiotics or probiotics in children with NAFLD. Results: Synbiotics (combined probiotics and prebiotics) modulate microbiota, reduce dysbiosis, improve intestinal permeability, and systemic inflammation and thereby affect liver health through gut-liver axis. Although previous findings have documented the potency of probiotic supplementation in improving , lipid profile, aminotransferase levels and hepatic steatosis in children with NAFLD, synbiotic supplementation failed to affect the disease in short interventional periods (12 weeks and 16 weeks, respectively). Based on our extensive search, only long-term (4 month) synbiotic supplementation along with lifestyle modifications affected hepatic steatosis (≥1 grade) and liver enzymes (especially aspartate aminotransferase) as well as oxidative/inflammatory state in children with NAFLD. These findings suggest that probiotic supplementation could be considered as a better choice in the management of pediatric NAFLD. Conclusion: Probiotic supplementation could be considered as a more effective adjuvant therapy for children with NAFLD, compared with synbiotic supplementation. However, further well-designed clinical trials are needed to confirm these preliminary findings.