سامانه کنگره های دانشگاه علوم پزشکی و خدمات بهداشتی و درمانی آذربایجان غربی

صفحه اصلی / بیستمین همایش سالیانه بیماری های شایع گوارش و کبد کودکان ایران و دومین همایش بین المللی چاقی کودکان

The Impact Of Postbiotics On Childhood Obesity : A Review

نویسندگان :

Aylin Ebrahimpour¹ Sajjad Moradi² Negar Moosaee Farahani³

1- دانشکده علوم پزشکی مراغه 2- دانشکده علوم پزشکی مراغه 3- دانشکده علوم پزشکی مراغه

کلمات کلیدی :

Postbiotic،Obesity،Children

چکیده :

Background and Aim: As a rapidly growing global health problem, childhood obesity requires a safe and effective intervention. Postbiotics, which are their inanimate microorganisms and bacterial components, could provide potential benefits without the risk associated with live probiotics. The purpose of this review was to clarify the influence of postbiotics on pediatric obesity. Methods: A systematic literature review was performed on scientific databases including PubMed, Web of Science and Google Scholar. The search included articles published until 2025 and employed keywords like “Postbiotics”, “Childhood” and “Obesity”. Results: Inactivated strains (Lactobacillus amylovorus, Bifidobacterium animalis subsp. lactis, Pediococcus pentosaceus) and butyrate significantly improved body composition, BMI, and metabolic markers in obese children.Butyrate reduced waist circumference, ghrelin levels, and enhanced glucose metabolism. Postbiotics (e.g., SCFAs like butyrate) increased energy expenditure, suppressed adipogenesis, and activated AMPK to regulate lipid metabolism. They modulated gut microbiota, strengthened gut barrier integrity, and reduced inflammation (e.g., IL-6, NF-κB downregulation). Eliminated risks of bacterial translocation, infections, and antibiotic resistance gene transfer (unlike live probiotics).Superior stability, dosing ease, and broader impacts (immunomodulation, gut-brain axis regulation) compared to paraprobiotics.A 6-month RCT and animal studies confirmed postbiotics’ efficacy in reducing obesity markers with no adverse effects.Potential Antibiotic Resistance Gene. Residual genetic material in some postbiotics may pose a theoretical risk of horizontal gene transfer to gut pathogens, though significantly lower than with probiotics.Rigorous screening of parent strains is critical to mitigate risks.Despite this, postbiotics remain safer for children due to their non-viable nature. Conclusion: Postbiotics, particularly short-chain fatty acids and heat-killed bacteria, have demonstrated significant anti-obesity effects in children by improving body composition, metabolic markers, and reducing inflammation. Their safety, stability, and lack of infection risk make them ideal for pediatric use. Although promising, further clinical trials are essential to optimize dosing and confirm long-term efficacy in childhood obesity management. Keywords: Postbiotics; Obesity; Children.