سامانه کنگره های دانشگاه علوم پزشکی و خدمات بهداشتی و درمانی آذربایجان غربی

صفحه اصلی / بیستمین همایش سالیانه بیماری های شایع گوارش و کبد کودکان ایران و دومین همایش بین المللی چاقی کودکان

Difference in Metabolically Healthy Versus Metabolically Unhealthy obesity in Children and Adolescents

نویسندگان :

Nastaran Vakilbashi¹ Golnaz Khodayari² Faezeh Ghalichi³

1- دانشگاه علوم پزشکی شهید بهشتی 2- دانشکده علوم پزشکی مراغه 3- دانشکده علوم پزشکی مراغه

کلمات کلیدی :

Metabolically Healthy Obesity،Metabolically Unhealthy Obesity،Children،Adolescents،Insulin Resistance،Cardiometabolic Risk

چکیده :

Background and Aim: Childhood obesity is a worldwide health problem that is becoming increasingly understood as a heterogeneous disorder. Thus, some obese children manifest metabolically healthy obesity (MHO), whereas others show cardiometabolic disturbances and are considered to have metabolically unhealthy obesity (MUO).We therefore aimed to examine demographic, anthropometric, and biochemical profiles of MHO and MUO phenotypes in children and adolescents, as well as to explore predictors of the unhealthy metabolic profile. Materials and Methods:This abstract summarizes results of recent observational and cross-sectional studies identified through PubMed, Embase and Scopus. Studies included children aged 6–18 years with obesity classified by BMI percentiles.MHO was defined as obesity in the absence of metabolic syndrome components (e.g., hypertension, dyslipidemia, insulin resistance), and MUO was defined as obesity with at least one metabolic abnormality. These variables included BMI z-scores; waist-to-height ratio; fasting glucose; insulin resistance (HOMA-IR); lipid profiles; serum uric acid levels; and inflammatory markers, including CRP. Results:The prevalence of the MHO phenotype in obese children across studies sedimented between 20–40%. Children with MHO were markedly younger, less obese (lower BMI z-scores), had a smaller waist circumferences and had significantly lower HOMA-IR values than children with MUO. MUO participants had increased triglyceride levels ,decreased HDL cholesterol, and elevated levels of systemic inflammation. On top of this, higher waist-to-height ratio and raised serum uric acid were common predictors of the MUO phenotype.The studies showed that MHO triad may progress to MUO over time and calls for long-term monitoring of these individuals. Conclusions:While some of children with obesity may initially display a metabolically health phenotype, this phenotype is not stable and may progress with time. The identification of MUO risk factors, especially early on, including abdominal obesity, insulin resistance, and elevated uric acid level, could avert the development of MUO through focused interventions.Stratifying obese children based on metabolic risk is crucial for designing personalized preventive strategies to curb long-term cardiovascular and metabolic complications.