0% Complete
صفحه اصلی
/
بیستمین همایش سالیانه بیماری های شایع گوارش و کبد کودکان ایران و دومین همایش بین المللی چاقی کودکان
Influenza and childhood obesity
نویسندگان :
Faezeh Mahd Gharebagh
1
Sadegh Feizollahzadeh
2
1- دانشگاه علوم پزشکی ارومیه
2- دانشگاه علوم پزشکی ارومیه
کلمات کلیدی :
Influenza،Immune Response،Childhood Obesity،Hospitalization،Vaccination
چکیده :
Background and Aim: Obesity has emerged as a novel and independent risk factor for increased morbidity and mortality due to influenza infections, particularly following the 2009 H1N1 pandemic . Although obesity is associated with several chronic non-communicable diseases, its impact on the immune response to viral infections such as influenza has only recently gained attention . Children, a high-risk group for influenza, are also increasingly affected by the global rise in obesity. This study aims to investigate the impact of childhood obesity on the clinical severity and immune response to influenza infection. . Methods: This research integrates data from human cohort studies, murine models, and clinical findings. Studies reporting immune responses and hospitalization rates among obese vs. non-obese children with influenza or influenza-like illness (ILI) were analyzed . Statistical tools such as odds ratios (OR) were used to quantify associations, controlling for age and comorbidities. Results: Obese children showed delayed cytokine responses and impaired T-cell activation, leading to poor infection clearance . Hospitalization odds in obese children infected with H1N1 influenza were significantly higher than in their healthy-weight peers (OR: 3.18 to 18.40) . Murine models confirmed more severe lung pathology and prolonged viral shedding in obese hosts. Despite adequate antibody levels post-vaccination, obese individuals experienced reduced vaccine effectiveness . Conclusion: Childhood obesity significantly increases the risk of severe influenza, including hospitalization and reduced vaccine efficacy. Obesity alters both innate and adaptive immune responses, calling for tailored public health strategies for prevention and treatment of influenza in obese pediatric populations.
لیست مقالات
لیست مقالات بایگانی شده
Fatty liver disease in overweight and obese Iranian Children: Comprehensive systematic review and meta-analysis
Milad Jalilian - Raheleh Rasad
Non-Alcoholic Fatty Liver Disease in Children: An Epidemiological Snapshot and Regional Considerations in Urmia, Iran
Adviya Ali - Saliha Muzaffer - Muhamed Rzgar
Terminological Analysis of Search Content Related to Colorectal, Ovarian, Breast, Uterine, and Skin Cancers Using Google Trends in Iran and Turkey
Yousef Mohammadpour - Shahram Ebrahimi Moradali - Vahid Hoseinpour - Rasul Bidel Nikoo - Saeideh Rahimi
Association of the higher ultra-processed food consumption with the odds of overweight and obesity amongst school-aged children: An umbrella meta-analysis of systematic review and meta-analyses of observational studies
Roghayeh Molani-Gol - Maryam Rafraf
Gastric Perforation Due to Inappropriate Heimlich Maneuver Following Foreign Body Ingestion
Fatemeh Pazhouman - Amirhossein Moussavi moghanjougi - Khadijeh Elgeztin - Ameneh Elgeztin
The impact of probiotic bacteria on healing and decreasing intestinal inflammation in children with cystic fibrosis
Mahdie Feizi Eliyas Abad - Mortaza Taheri-Anganeh - Mohammad Reza Asgharzadeh - Ebrahim Mazloomi - Hadi Maleki-Kakelar
A Review of the Impact of Lifestyle on the Increase of Functional Gastrointestinal Disorders in Children
Elahe Karimipour - Haniye Karimipour
The Importance of Assessing Gastrointestinal Pain in Children After Hair Ingestion
Fatemeh Pazhouman - Amirhossein Moussavi moghanjougi - Khadijeh Elgeztin - Ameneh Elgeztin
The Role of Nutrition in Managing Obesity in Children with ADHD: A Narrative Review
Fatemeh Yousefi - Zahra Mosavi Shirazifard
The Effect of Peiminine on the Levels of Antioxidant Enzymes in the Liver Tissue of Male Wistar Rats with Non-Alcoholic Fatty Liver Disease
Bahman Mansouri Motlagh - Belal Pashaei - ُShahsanam Gheibi
بیشتر
ثمین همایش، سامانه مدیریت کنفرانس ها و جشنواره ها - نگارش 42.4.2