سامانه کنگره های دانشگاه علوم پزشکی و خدمات بهداشتی و درمانی آذربایجان غربی

صفحه اصلی / بیستمین همایش سالیانه بیماری های شایع گوارش و کبد کودکان ایران و دومین همایش بین المللی چاقی کودکان

Influenza and childhood obesity

نویسندگان :

Faezeh Mahd Gharebagh¹ Sadegh Feizollahzadeh²

1- دانشگاه علوم پزشکی ارومیه 2- دانشگاه علوم پزشکی ارومیه

کلمات کلیدی :

Influenza،Immune Response،Childhood Obesity،Hospitalization،Vaccination

چکیده :

Background and Aim: Obesity has emerged as a novel and independent risk factor for increased morbidity and mortality due to influenza infections, particularly following the 2009 H1N1 pandemic . Although obesity is associated with several chronic non-communicable diseases, its impact on the immune response to viral infections such as influenza has only recently gained attention . Children, a high-risk group for influenza, are also increasingly affected by the global rise in obesity. This study aims to investigate the impact of childhood obesity on the clinical severity and immune response to influenza infection. . Methods: This research integrates data from human cohort studies, murine models, and clinical findings. Studies reporting immune responses and hospitalization rates among obese vs. non-obese children with influenza or influenza-like illness (ILI) were analyzed . Statistical tools such as odds ratios (OR) were used to quantify associations, controlling for age and comorbidities. Results: Obese children showed delayed cytokine responses and impaired T-cell activation, leading to poor infection clearance . Hospitalization odds in obese children infected with H1N1 influenza were significantly higher than in their healthy-weight peers (OR: 3.18 to 18.40) . Murine models confirmed more severe lung pathology and prolonged viral shedding in obese hosts. Despite adequate antibody levels post-vaccination, obese individuals experienced reduced vaccine effectiveness . Conclusion: Childhood obesity significantly increases the risk of severe influenza, including hospitalization and reduced vaccine efficacy. Obesity alters both innate and adaptive immune responses, calling for tailored public health strategies for prevention and treatment of influenza in obese pediatric populations.

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