سامانه کنگره های دانشگاه علوم پزشکی و خدمات بهداشتی و درمانی آذربایجان غربی

صفحه اصلی / بیستمین همایش سالیانه بیماری های شایع گوارش و کبد کودکان ایران و دومین همایش بین المللی چاقی کودکان

Efficacy and Safety of Pharmacological Interventions in Managing Cardiometabolic Risk Factors in Obese and Overweight Youth: A Systematic Review and Network Meta-Analysis

نویسندگان :

Amir Hossein Faghfouri¹ Amin Mokari-Yamchi² Shahsanam Gheibi³

1- دانشگاه علوم پزشکی ارومیه 2- دانشگاه علوم پزشکی ارومیه 3- دانشگاه علوم پزشکی ارومیه

کلمات کلیدی :

Network meta-analysis،Obesity،Pharmacological Interventions،Cardiometabolic Risk Factors

چکیده :

Background: Obesity has become a growing global health concern among young people. This meta-analysis seeks to systematically assess the efficacy and safety of pharmaceutical interventions in improving body weight, body mass index (BMI), waist circumference (WC), diastolic blood pressure (DBP), fasting blood sugar (FBS), and lipid profiles, planned prior to data collection. Methods: We conducted a comprehensive literature search on PubMed, Scopus, Embase, Web of Science, and the Cochrane Library, covering studies published up to September 2024. Randomized clinical trials (RCTs) were included if they reported efficacy of weight-loss medications in youth populations aged 2-20 years. Direct and indirect evidence were synthesized using a frequentist framework. Results: Pooled analysis on 30 RCTs showed that high dose phentermine/topiramate was more effective in reducing weight (MD: -15.8 kg; 95%CI: -19.17 to -12.43; p<0.001; P-scores= 0.998;), BMI (MD= -5.35 kg/m2; 95% CI: -8.03, -2.67; p <0.001; P-scores= 0.976;), WC (MD= -7.69 cm; 95% CI: -10.19, -5.18; p <0.001; P-scores= 0.989), and BMI percentile (MD: -20.25; 95%CI: -24.82 to 95% CI: -20.38 to -1.62; p=0.021) compared to placebo. Orlistat (MD= -1.81 mmHg; 95% CI: -2.94, -0.68; p=0.002; P-scores= 808), metformin (MD: -0.14 unit; 95%CI: -0.23 to -0.04; p=0.005; P-scores= 0.799), liraglutide (MD: -11.00 mg/dl; 95% CI: -20.38 to -1.62; p=0.021) were more effective in improving DBP, BMI-z score, and FBS, respectively. Lipid profile and SBP were not affected by studied drugs. Conclusion: High- and moderate-dose phentermine/topiramate was more effective than a placebo in reducing anthropometric measures in youth with overweight and obesity. Liraglutide and metformin result in a significant reduction in FBS levels compared to placebo.