سامانه کنگره های دانشگاه علوم پزشکی و خدمات بهداشتی و درمانی آذربایجان غربی

صفحه اصلی / بیستمین همایش سالیانه بیماری های شایع گوارش و کبد کودکان ایران و دومین همایش بین المللی چاقی کودکان

The Interplay of Vitamin D Deficiency and Insulin Resistance in Obese Children and Adolescents: A Cross-Sectional Analysis of Metabolic Dysregulation and Therapeutic Implications

نویسندگان :

Aydin Mahmoud Alilou¹ Roghayeh Faraji Akhijahani² Pouria Shieeh³ Alisan Khodayarlo⁴ Sina Manouchehrnia⁵ Sana Nasirpour⁶ Meysam Najafi⁷ Parinaz Mahmoud Alilou⁸ Reza Rostami⁹ Amir Reza Bana Nasli¹⁰ Amir Hossein Eskandari¹¹ Asal Khaksar Kolvanagh¹² Pardis Pour Ali¹³

1- دانشگاه علوم پزشکی تبریز 2- دانشگاه علوم پزشکی تبریز 3- دانشگاه علوم پزشکی تبریز 4- دانشگاه علوم پزشکی تبریز 5- دانشگاه علوم پزشکی تبریز 6- دانشگاه علوم پزشکی تبریز 7- دانشگاه علوم پزشکی تبریز 8- دانشگاه علوم پزشکی تبریز 9- دانشگاه علوم پزشکی تبریز 10- دانشگاه علوم پزشکی تبریز 11- دانشگاه علوم پزشکی تبریز 12- دانشگاه علوم پزشکی تبریز 13- دانشگاه علوم پزشکی تبریز

کلمات کلیدی :

Pediatric obesity،Vitamin D deficiency،Insulin resistance،HOMA-IR،Metabolic syndrome

چکیده :

Background and Aim: Childhood obesity is a global epidemic linked to metabolic complications, including insulin resistance (IR) and vitamin D (vit D) deficiency. While the association between obesity and IR is established, the role of vit D in modulating IR among obese pediatric patients remains underexplored. This study investigates the relationship between vit D deficiency and IR in obese children, proposing targeted interventions to mitigate metabolic risks. Methods: A cross-sectional study of 150 obese children (BMI ≥95th percentile, aged 6–18 years) was conducted. Serum 25-hydroxyvitamin D (25(OH)D), fasting glucose, insulin, and HOMA-IR were measured. Demographic, anthropometric, and lifestyle data were collected. Statistical analyses included multivariate regression and subgroup stratification. Results: Vit D deficiency (25(OH)D <20 ng/mL) was prevalent in 58% of participants. HOMA-IR ≥2.5 was observed in 47%. Inverse correlations between 25(OH)D and HOMA-IR (r = -0.42, p <0.001) and BMI z-score (r = -0.38, p = 0.002) were identified. Severe obesity (BMI z-score >3) amplified IR risk (OR = 3.1, 95% CI: 1.8–5.4). Sedentary behavior (>4 hours/day screen time) independently predicted lower 25(OH)D levels (β = -6.2, p = 0.01). Conclusion: Vit D deficiency exacerbates IR in obese children, particularly in severe obesity. Integrative interventions combining high-dose vit D supplementation and lifestyle modification are proposed to address this metabolic synergy.