سامانه کنگره های دانشگاه علوم پزشکی و خدمات بهداشتی و درمانی آذربایجان غربی

صفحه اصلی / بیستمین همایش سالیانه بیماری های شایع گوارش و کبد کودکان ایران و دومین همایش بین المللی چاقی کودکان

Probiotics reduce inflammatory indicators and diarrhea in children

نویسندگان :

Mahdie Feizi Eliyas Abad¹ Mortaza Taheri-Anganeh² Mohammad Reza Asgharzadeh³ Ebrahim Mazloomi⁴ Hadi Maleki-Kakelar⁵

1- دانشگاه علوم پزشکی ارومیه 2- دانشگاه علوم پزشکی ارومیه 3- دانشگاه آزاد اسلامی واحد ارومیه 4- دانشگاه علوم پزشکی ارومیه 5- دانشگاه علوم پزشکی ارومیه

کلمات کلیدی :

probiotics،Lactobacillus casei،immunoglobulin A (IgA)،lactoferrin،calprotectin

چکیده :

Background and Aim: Chronic diarrhea is a leading cause of pediatric morbidity. The purpose for this study aimed to look at how probiotics affected clinical symptoms, gut microbiota, including inflammatory markers during naive diarrhea. Methods: Children aged 12 months to 6 years hospitalized with acute diarrhea were randomly allocated to receive probiotics (Lactobacillus casei; n=32) or no probiotics (n=20) orally twice daily for 7 days. Stool samples were also obtained to determine bacterial composition using standard agar plates and sequencing. Enzyme-linked immunosorbent assay (ELISA) was used to quantify and compare immunoglobulin A (IgA), lactoferrin, and calprotectin levels across groups. Other clinical signs or symptoms, such as fever, vomiting, diarrhea, stomach discomfort, flatulence, daily intake, hunger, and body weight, were also evaluated. Results: Data were gathered from 52 participants at three distinct periods. The probiotic group had significantly greater total fecal IgA levels in their stool extract compared to the control group (p<0.05). Patients who consumed the probiotic Lactobacillus casei (LCG) had substantially lower fecal lactoferrin and calprotectin levels compared to the control group (p<0.05). The findings acquired one week following enrollment suggest that administering the probiotic LCG may be effective for modifying the gut flora. The probiotic group's stool culture showed an increase in bifidobacteria and lactobacillus species. Appetite and food intake, body weight increase, stomach discomfort, bloating, and bowel movements (diarrhea) were considerably improved in children given the probiotic compared to the control group. Conclusion: During LCG treatment for acute diarrhea, fecal IgA levels rose. In contrast, acute diarrhea treated with LCG reduced fecal lactoferrin and calprotectin levels. The LCG probiotic may be a beneficial supplement for use in children during acute diarrhea to lower clinical severity and intestinal inflammatory response.