سامانه کنگره های دانشگاه علوم پزشکی و خدمات بهداشتی و درمانی آذربایجان غربی

صفحه اصلی / بیستمین همایش سالیانه بیماری های شایع گوارش و کبد کودکان ایران و دومین همایش بین المللی چاقی کودکان

The potential properties of dietary polyphenols in controlling childhood obesity

نویسندگان :

Razieh Vaezi¹ Laleh Payahoo² Mohaddeseh Ghahremani³ Yaser Khajebishak⁴

1- دانشکده علوم پزشکی مراغه 2- دانشکده‌ علوم پزشکی مراغه 3- دانشکده علوم پزشکی مراغه 4- دانشکده علوم پزشکی مراغه

کلمات کلیدی :

Inflammation،Childhood obesity،Polyphenol،Antioxidant،Metabolism

چکیده :

Background and Aim: Childhood obesity has emerged as one of the serious health challenges of the 21st century. Given the recent shifts in lifestyle behaviors, particularly dietary habits, identifying effective preventive nutritional factors is of growing importance. Polyphenols, naturally occurring compounds found in fruits, vegetables, and beverages, have gained attention as potential agents in the prevention of childhood obesity due to their antioxidant and anti-inflammatory properties. The present study aims to explore the mechanisms of action of the key dietary polyphenols in the context of childhood obesity prevention and management. Methods: In this review paper, a comprehensive literature review was conducted using scientific databases including PubMed, Web of Science, Scopus, and Google Scholar using keywords such as "Polyphenol", "Antioxidant", "Inflammation", " Metabolism " and "Childhood obesity" from 2000 to 2025. Results: Major dietary sources of polyphenols with reported anti-obesity effects include resveratrol, anthocyanins, anthocyanidins, flavanonols, curcumin, anthocyanins and catechins. These compounds exert anti-obesity effects through various biological mechanisms such as inhibiting angiogenesis, suppressing adipocyte proliferation and differentiation, down-regulating enzymes involved in fatty acid oxidation, and reducing intestinal fat absorption. Insulin resistance and chronic low-grade inflammation are considered hallmark features of obesity. Polyphenols may enhance insulin sensitivity and modulate inflammatory responses by suppressing the production of pro-inflammatory cytokines and disrupting inflammatory signaling pathways. As well, polyphenols contribute to modulation of gut microbiota dysbiosis common in obese children. These components promote the production of short chin fatty acids (SCFAs), reduce level of lipopolysaccharides (LPS) and branched-chain amino acids (BCAAs) which all of them intensify gut inflammation and metabolic dysfunction in the gut. Conclusion: Given the beneficial effects of most dietary polyphenols on energy metabolism, inflammation and gut microbiota, it is recommended to incorporate these dietary factors in regular children's diet. However, it is important to note that high doses of polyphenols can be accompanied by complications and should be attended to. Further clinical trials are needed to establish optimal dosing and long-term safety assessment in children.