سامانه کنگره های دانشگاه علوم پزشکی و خدمات بهداشتی و درمانی آذربایجان غربی

صفحه اصلی / بیستمین همایش سالیانه بیماری های شایع گوارش و کبد کودکان ایران و دومین همایش بین المللی چاقی کودکان

The Impact of Chitosan Supplementation on Gut Microbiota in Overweight or Obese Adolescents: A Randomized, Double-Blind Clinical Trial

نویسندگان :

Somaye Fatahi¹

1- علوم پزشکی شهید بهشتی

کلمات کلیدی :

obesity،Chitosan،pediatric،supplement

چکیده :

Background: Overweight and obesity have been associated with an altered intestinal microbiome. Recent investigations have demonstrated that fiber supplementation, including chitosan, can exert beneficial and protective effects on the composition of gut microbiota in humans diagnosed with overweight/obesity. However, there is still a great deal of heated debate regarding the impact of chitosan supplementation in overweight and obese adolescents. Therefore, the aim of this study is to clarify the effects of chitosan administration on the composition of the gut microbiome in overweight and obese adolescents. Methods and analysis: Sixty-four overweight and obese adolesences were subjected to supplementation with 3 g of chitosan for 12 weeks. Anthropometric indices and physical activity were measured at the beginning and at the end of the intervention. After DNA extraction and purification, the quantity of bacteria in the patients’ stool samples was determined by real-time polymerase chain reaction (PCR). The RCT was registered on the Iranian Registry of Clinical Trials (www.irct.ir) website (IRCT20091114002709N57; registration date: 2021-06-20). Results: Individuals who received chitosan supplementation experienced a significant decrease in the BMI z-score (P < 0.001). Administration of chitosan led to notable changes in Firmicutes (P<0.001), Bacteroidetes (P=0.008), Akkermansia (P<0.001) populations, respectively, and of the ratio of Firmicutes to Bacteroidetes (P<0.001). Mean changes in Lactobacillus populations were marginally significant (P=0.05). Chitosan administration did not alter the composition in Bifidobacterium populations (P=0.97) Conclusion: The present study demonstrates beneficial effects of chitosan administration on some bacterial species associated with overweight and obesity in adolescents. Further research is needed to confirm our findings and clarify the impact of this intervention on the Lactobacillus population in the gut.