سامانه کنگره های دانشگاه علوم پزشکی و خدمات بهداشتی و درمانی آذربایجان غربی

صفحه اصلی / بیستمین همایش سالیانه بیماری های شایع گوارش و کبد کودکان ایران و دومین همایش بین المللی چاقی کودکان

Can Pre-/Pro and Synbiotics Affect Cardiovascular Risk Factors in Children and Adolescence with Overweight and Obesity? A Grade-Assessed Systematic Review and Meta-Analysis of Randomized Controlled Trials

نویسندگان :

Fatemeh Faramarzi¹ Amir Hossein Faghfouri²

1- دانشگاه علوم پزشکی تبریز 2- دانشگاه علوم پزشکی ارومیه

کلمات کلیدی :

Probiotics،Prebiotics،Synbiotics،Obesity،Pediatrics

چکیده :

Background: Gut microbiota modulation has been proposed as a potential intervention for managing obesity. This meta-analysis aimed to evaluate the effects of prebiotic/probiotic/synbiotic supplementation on cardiometabolic risk factors in obese pediatrics. Methods: A comprehensive search was conducted in databases up to January 2025. Randomized controlled trials (RCTs) evaluating prebiotics/probiotics/synbiotics in children and adolescents with overweight/obesity were included. The outcomes were body weight (BW), body mass index (BMI), BMI-z score, fasting blood sugar (FBS), homeostatic model assessment for insulin resistance (HOMA-IR), insulin, hemoglobin A1c (HbA1c), total cholesterol (TC), triglycerides (TG), low-density lipoprotein-cholesterol (LDL-C), and high-density lipoprotein-cholesterol (HDL-C). Data were pooled using a random-effects model. Results: Meta-analysis showed no significant effect of prebiotic/probiotic/synbiotic supplementation on weight (WMD = -0.25; 95% CI: -1.96, 1.47), BMI (WMD = -0.18; 95% CI: -0.66, 0.29), BMI-z score (WMD = -0.02; 95% CI: -0.12, 0.05), FBS (WMD = -0.27; 95 % CI: -1.11, 0.57), insulin (WMD = 0.70; 95 % CI: -1.18, 2.59), HOMA-IR (WMD = 0.24; 95 % CI: -0.28, 0.75), TG (WMD = -0.73; 95% CI: -7.11 to 8.57), TC (WMD = 0.99; 95% CI: -4.24 to 2.25), LDL-C (WMD = 0.240; 95% CI: -3.65 to 3.18), and HDL-C (WMD = -1.04; 95% CI: -3.18 to 1.05). However, a significant reduction in FBS with probiotics (P < 0.001). Sensitivity analysis revealed a significant decrease in weight, FBS, and HDL-C (P < 0.05). Conclusion: Prebiotic/probiotic/synbiotic supplementation cannot improve cardiometabolic risk factors in overweight and obese children, except for a beneficial effect of probiotics on FBS.