سامانه کنگره های دانشگاه علوم پزشکی و خدمات بهداشتی و درمانی آذربایجان غربی

صفحه اصلی / بیستمین همایش سالیانه بیماری های شایع گوارش و کبد کودکان ایران و دومین همایش بین المللی چاقی کودکان

Evaluation of Immunological indices related to Gluten sensitivity and the prevalence of inherited Immunoglobulin type A deficiency in patients with Autism Spectrum Disorders in Tabriz

نویسندگان :

Faezeh Ghalichi¹ Alireza Ostadrahimi²

1- دانشکده علوم پزشکی مراغه 2- دامشگاه علوم پزشکی تبریز

کلمات کلیدی :

Autism spectrum disorders،Gluten،Immunoglobulin A،human leukocyte antigen،pathogen

چکیده :

Background and Aim: The term Autism Spectrum Disorder (ASD) refers to a range of neurodevelopmental disorders that include the more specific diagnoses of autism, Asperger syndrome, and Pervasive Developmental Disorder not otherwise specified. The defining features of ASD include impairments in social interaction, communication, imagination, restricted interests, and stereotypic behaviors. Immunological dysfunction is a recognized feature in ASD. The Human Leukocyte Antigen (HLA) genes are among the strongest predictors of risk for autoimmune conditions and are associated with neurodevelopmental disorders, such as schizophrenia and ASD. The objectives of this study were to evaluate the immunological indices related to Gluten sensitivity and the prevalence of inherited Immunoglobulin type A deficiency in patients with Autism Spectrum Disorders in Tabriz. Methods: The present cross-sectional study was performed over 80 subjects diagnosed with ASD, ages 4-16. After convenient and accessible sampling and considering inclusion and exclusion criteria, patients entered the research. Fasting Blood samples were obtained and immunological measure consisting of IgA, tTGIgA, tTGIgG and EMAIgG were analyzed. Results: The average age of children was 7.90±3.35 (58 boys and 22 girls). The mean IgA in this study was 104.28±49.93 mg/dl. 9 patients were identified with IgA deficiency. The tTGIgA of 9 individuals was above 12 U/ml and 2 patients were in borderline (8-12 U/ml). tTGIgG and EMAIgG were not positive for any of the patients with IgA deficiency. Conclusion: Inherited deficiency of the immune system may prevent the patient from clearing a pathogen in a timely and normal fashion, placing the patient at higher risk for the pathogen to interfere with brain development and triggering an autoimmune response resulting in the symptoms of ASD. According to the results obtained from this research, there were immunity dysfunctions in children with ASD and therefore raises the importance of providing suitable strategies to support their immune system.

لیست مقالات

لیست مقالات بایگانی شده

The effectiveness of group training based on the Bakroid method on improving eating attitudes and increasing self-esteem in obese adolescent girls

Fateme Mohammadi - Ghazaleh Orouji - Kowsar Soltani - Khadijh Mohammadi - Zahra Mohammadi

Evaluation of the effect of Covid 19 pandemic on Body Mass Index of primary school students in Urmia

Seiedeh fatemeh Hoseinlar - Shahsanam Gheibi - Mohammed Heeidari - Behnam Haghverdizadeh

The Effect of the Ketogenic Diet on Obese Children: A review study

Mohammad Kazem Imani Khoshkhoo - Hady Mabzoul - Soona Heydaripour

The Association between VITAMIN E INTAKE and Non-Alcoholic Fatty Liver Disease : An Umbrella Systematic Review , Meta-analysis.

Sadra Khodaei Alamdari - Sajjad Moradi - Kosar Rajabi

Can Pre-/Pro and Synbiotics Affect Cardiovascular Risk Factors in Children and Adolescence with Overweight and Obesity? A Grade-Assessed Systematic Review and Meta-Analysis of Randomized Controlled Trials

Fatemeh Faramarzi - Amir Hossein Faghfouri

The Interplay of Vitamin D Deficiency and Insulin Resistance in Obese Children and Adolescents: A Cross-Sectional Analysis of Metabolic Dysregulation and Therapeutic Implications

Aydin Mahmoud Alilou - Roghayeh Faraji Akhijahani - Pouria Shieeh - Alisan Khodayarlo - Sina Manouchehrnia - Sana Nasirpour - Meysam Najafi - Parinaz Mahmoud Alilou - Reza Rostami - Amir Reza Bana Nasli - Amir Hossein Eskandari - Asal Khaksar Kolvanagh - Pardis Pour Ali

Investigating risk factors for nonalcoholic fatty liver disease as the most common chronic liver disease in children

Fatemeh Pourmohammad - Masoumeh Akbarbegloo - Ali Rahimlou

Cross-Sectional Cohort Study: Bariatric Surgery Outcomes in Adolescents Under 18 Years

Amirhossein Hosseini - Alireza Khalaj - Maryam Barzin - Mina Alibeik - Soheil Omid

The importance and potential of probiotics in addressing childhood obesity by influencing gut microbiota.

Nazanin Mozaffari - Mohsen Maleki

Gut Microbiome and Pediatric Obesity :A Review

Aylin Ebrahimpour - Faezeh Ghalichi - Negar Moosaee Farahani

بیشتر

ثمین همایش، سامانه مدیریت کنفرانس ها و جشنواره ها - نگارش 42.4.2