سامانه کنگره های دانشگاه علوم پزشکی و خدمات بهداشتی و درمانی آذربایجان غربی

صفحه اصلی / بیستمین همایش سالیانه بیماری های شایع گوارش و کبد کودکان ایران و دومین همایش بین المللی چاقی کودکان

The Association between Selenium Intake and Cancer Risk: An Umbrella Systematic Review , Meta-analysis and observational studies.

نویسندگان :

Sadra Khodaei Alamdari¹ Aylin Ebrahimpour² Negar Moosaee Farahani³

1- دانشکده علوم پزشکی مراغه 2- دانشکده علوم پزشکی مراغه 3- دانشکده علوم پزشکی مراغه

کلمات کلیدی :

Selenium،Cancer،Selenium Supplement،Dietary Selenium Intake،Cancer Risk،Liver Cancer

چکیده :

Abstract Background and Aims : Selenium, a trace element with antioxidant and anti-inflammatory properties, has been extensively studied for its potential in cancer prevention.Despite promising findings, the evidence regarding selenium intake (dietary and supplemental) and cancer risk remains inconsistent. Methods : We conducted an umbrella review of 14 meta-analyses comprising 78 studies with diverse designs(RCTs, cohort, and case-control studies).Relative risks (RRs) and 95% confidence intervals (CIs) were extracted, and heterogeneity was assessed using the I² statistic.Cancer types included gastrointestinal, pancreatic, liver, breast, prostate, esophageal, lung, bladder, head and neck, and skin cancers.Data were analyzed for dietary and supplemental selenium intake separately. Results: This umbrella review synthesizes evidence from 13 meta-analyses examining selenium intake and cancer risk. Dietary selenium was associated with significantly reduced risks of gastrointestinal cancer(RR: 0.49, 95% CI: 0.36–0.67) and pancreatic cancer (RR: 0.47, 95% CI: 0.26–0.85). Selenium supplementation showed protective effects against liver cancer (RR: 0.52, 95% CI: 0.35–0.79) and pancreatic cancer (RR: 0.659, 95% CI: 0.489–0.889).However, no significant associations were found for breast, head and neck, esophageal, melanoma, non-melanoma skin, lung, prostate, or bladder cancers. Notably, selenium supplementation was linked to a non-significant increased risk of breast cancer(RR: 1.44, 95% CI: 0.96–2.17). Heterogeneity varied across studies, with some showing moderate to high inconsistency(I² up to 82.2%).These findings highlight context-dependent effects of selenium on cancer risk. Conclusion: Dietary selenium appears protective against gastrointestinal, liver, and pancreatic cancers, while effects of supplementation remain inconsistent.Further studies are needed to clarify the impact of selenium sources, doses, and duration on cancer risk.